Product Description
Ipamorelin is a selective growth hormone secretagogue that acts as a ghrelin receptor agonist. Unlike other GHRPs, ipamorelin has minimal effects on cortisol and prolactin, making it the cleanest GHRP for research. It's commonly stacked with CJC-1295 for synergistic GH elevation.
Research Applications
- Selective GH secretion research
- Synergistic GHRH/GHRP studies
- Muscle growth signaling
- Recovery and repair research
- Minimal side effect profile studies
Quality Assurance
- HPLC Analysis: Verified 99.5%+ purity
- Mass Spectrometry: Confirmed molecular weight
- Endotoxin Testing: <0.1 EU/mg
- Third-Party Verification: Independent lab COA included
⚠️ Important Research Notice
This product is intended solely for laboratory research. Not approved for human consumption or clinical use.
Research Applications & Mechanisms
Mechanism of Action
Selective Ghrelin Receptor Agonist
Ipamorelin is a selective growth hormone secretagogue that acts as a ghrelin receptor agonist. Unlike other GHRPs, ipamorelin has minimal effects on cortisol and prolactin, making it the cleanest GHRP for research. It's commonly stacked with CJC-1295 for synergistic GH elevation.
Primary Research Areas
- Selective GH secretion research
- Synergistic GHRH/GHRP studies
- Muscle growth signaling
- Recovery and repair research
- Minimal side effect profile studies
Pharmacokinetic Profile
- Half-Life: 2 hours
- Dosing Frequency: 2-3x daily
- Purity: 99.5%+ (HPLC verified)
Ipamorelin Research & Scientific Studies
The following information is based on published scientific research and clinical studies.
All research cited is from peer-reviewed journals and represents current scientific understanding
of this compound's mechanisms and effects.
Selective Growth Hormone Release
Ipamorelin is the most selective growth hormone releasing peptide (GHRP), producing robust GH elevation with minimal effects on cortisol, prolactin, and appetite. Research shows 3-5 fold increases in GH levels within 30 minutes of administration.1
Unlike other GHRPs, ipamorelin does not significantly activate cortisol or prolactin release, making it the cleanest GHRP for research applications. This selectivity reduces potential side effects and makes it suitable for long-term studies.2
Studies demonstrate that ipamorelin maintains its efficacy with repeated dosing, showing minimal tachyphylaxis compared to other GHRPs like GHRP-6 or hexarelin.3
Synergistic Effects with GHRH
When combined with GHRH analogs like CJC-1295, ipamorelin produces synergistic GH elevation. Research shows the combination can increase GH levels 10-20 fold—far greater than either peptide alone.4
This synergy occurs because the peptides act through different mechanisms: GHRH stimulates GH synthesis and release, while ipamorelin amplifies the GH pulse through ghrelin receptor activation. Together, they create a more physiological GH secretion pattern.5
Studies demonstrate that the CJC-1295/ipamorelin combination is one of the most effective and well-tolerated approaches for sustained GH elevation in research models.6
References
- Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-61.
- Johansen PB, et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res. 1999;9(2):106-13.
- Gobburu JV, et al. Pharmacokinetic-pharmacodynamic modeling of ipamorelin. J Clin Pharmacol. 1999;39(6):664-73.
- Bowers CY. Growth hormone-releasing peptide (GHRP). Cell Mol Life Sci. 1998;54(12):1316-29.
- Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018;6(1):45-53.
- Khatib MN, et al. Growth hormone secretagogue treatment in hypogonadal men. Eur J Endocrinol. 2014;171(2):213-8.
⚠️ Research Disclaimer
This information is provided for educational and research purposes only. These studies
were conducted in laboratory settings and/or clinical trials. This product is intended
solely for research use and is not approved for human consumption or clinical applications.
